Today, elite migration is one of issues in Iran. Therefore, aim of this study is to investigate relationships between entrepreneurial spirit, academic performance, and propensity to immigrate among students using a structural equation approach using a descriptive-correlational method. Online questionnaires were collected from students at Ferdowsi University and Mashhad Medical Sciences during two months (October and November 2017). Research findings showed that among dimensions of entrepreneurial spirit, achievement-seeking dimension received the highest score and risk-taking dimension received the lowest score. The results of Pearson test indicate that the higher the entrepreneurial spirit in students, the higher their propensity to immigrate. The results of the Spearman correlation coefficient test also showed that there is a positive relationship with a magnitude of 0.378 between two variables of quality of academic life and tendency to migrate, and the higher quality of academic life of students, the higher their tendency to migrate. The results of structural equation model indicated that entrepreneurial spirit has a positive effect on academic performance with a standard coefficient of 0.605 and students with a stronger entrepreneurial spirit have better academic performance. Entrepreneurial spirit also has an effect on the tendency to migrate with a coefficient of 0.527 and students with a stronger entrepreneurial spirit show a greater tendency to migrate. Academic performance also has an effect on the tendency to migrate with a coefficient of 0.111 (with a lower intensity than the previous two factors). Based on the results, it is suggested that use of entrepreneurial spirit in the form of university-industry relations and projects related to entrepreneurship of students of Ferdowsi University of Medical Sciences of Mashhad; should be such that it can play an effective role in reducing their tendency to migrate.